Polyneuropathy

Polyneuropathy is a disease of the peripheral nerves. Unlike mononeuropathy, it affects many nerves. Each peripheral nerve has a specific function, so the symptoms depend on the type of nerves affected. The peripheral nerves are:

Sensory - transmitting sensory signals (temperature, pain, vibration, or touch) from the skin to the brain
Motor - controlling the movement of muscles
Autonomous - controlling functions such as blood pressure, heart rate, digestion, and bladder

Polyneuropathy is a nerve injury that can be caused by a number of conditions. Polyneuropathy can be caused by trauma, infection, metabolic diseases, genetic mutations, and toxins such as:

Diseases:
Autoimmune diseases - Sjogren's syndrome, lupus, rheumatoid arthritis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and vasculitis.
Diabetes - More than half of people with diabetes develop some form of neuropathy.
Infections - viral or bacterial infections, including Lyme disease, shingles, Epstein-Barr virus, hepatitis B and C, prognosis, diphtheria, and HIV.
Hereditary diseases - Charcot-Marie-Tooth disease
Tumors - malignant and benign tumors
Bone marrow disorders. It includes abnormal protein in the blood (monoclonal gammopathy), a form of bone cancer (myeloma), lymphoma, and the rare disease amyloidosis.

Poisons
Alcoholism - can lead to vitamin deficiency.
Exposure to poisons - industrial chemicals and heavy metals such as lead and mercury.
Medications - (eg chemotherapy) can cause polyneuropathy.

Slowly worsening tingling, tingling and numbness in the legs and arms, starting in the toes and spreading upwards (receiving the hands and feet wrapped in cotton)
Acute, throbbing, and burning pain
Painful hypersensitivity to touch
Lack of coordination and unstable gait
Muscle weakness and paralysis Used as if you were wearing gloves or socks when you weren't
If the autonomic nerves are affected, recognized, and may be involved:
Fuel intolerance
Excessive sweating or inability to sweat
Problems with the intestines, bladder, or digestion
Changes in blood pressure