Dr. Guentchev received his M.D. and Ph.D. from the University of Vienna, Austria where he also completed his Residency in neurosurgery. From 2001 to 2004 he went on to become a Visiting Fellow at National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD. Since 2011 he is Head of Unit at the Dept of neurosurgery, Klinikum Idar-Oberstein, Germany, training hospital of the Johannes Gutenberg-University Mainz. Since 2015 Dr. Marin Guentchev is Ass. Professor (Privatdozent) at the University of Heidelberg, Germany. Since 2015 Dr. Guentchev is Director of Trinity Medical Center, Sofia, Bulgaria.
Dr. Guentchev's professional interests include complex spinal surgery and pain treatment.
Dr. Guentchev's main research interests are focused on the molecular biology of primary brain tumours. Recent results from his research group were published 2014 in the peer reviewed journal Cancer. Further, Dr. Guentchev published a novel method for treating therapy resistant Sacroiliac Joint Pain via neurostimulation. These results were published in Neuromodulation the official journal of the International Neuromodulation Society.
For his research, Dr. Guentchev received following scientific awards: 2014 DGNC Posterpreis Neuromodulation, 2002 Pfizer Österreich ZNS Preis, 2000 Pfizer Österreich ZNS Preis, 1999 Erste Bank Preis der Österreichischen Ärztekammer, 1998 EFNS Meeting, Poster Prise.
Guentchev M, Preuss C, Rink R, Peter L, Sailer M, Tuettenberg J. Long-Term Reduction of Sacroiliac Joint Pain With Peripheral Nerve Stimulation. Operative neurosurgery, 2017 Oct;13(5):634–639. PubMed: 28922873
Sailer MH, Sarvepalli D, Brégère C, Fisch U, Guentchev M, Weller M, Guzman R, Bettler B, Ghosh A, Hutter G. An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery. J Vis Exp. 2016 Aug 23;(114). PubMed: 27583933
Birner P, Tchorbanov A, Natchev S, Tuettenberg J, Guentchev M. The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner. J Clin Pathol. 2015 Oct;68(10):830-4. PubMed: 26109200
Guentchev M, Preuss C, Rink R, Peter L, Wocker EL, Tuettenberg J. Technical Note: Treatment of Sacroiliac Joint Pain with Peripheral Nerve Stimulation. Neuromodulation. 2015 Jul;18(5):392-6. PubMed: 25354279
Birner P, Pusch S, Christov C, Mihaylova S, Toumangelova-Uzeir K, Natchev S, Schoppmann SF, Tchorbanov A, Streubel B, Tuettenberg J, Guentchev M. Mutant IDH1 inhibits PI3K/Akt signaling in human glioma. Cancer. 2014 Aug 15;120(16):2440-7. PubMed: 24771584
Birner P, Toumangelova-Uzeir K, Natchev S, Guentchev M. Expression of mutated isocitrate dehydrogenase-1 in gliomas is associated with p53 and EGFR expression. Folia Neuropathol. 2011;49(2):88-93. PubMed: 21845536
Maresch J, Birner P, Zakharinov M, Toumangelova-Uzeir K, Natchev S, Guentchev M. Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma. Cancer. 2011 Jun 1;117(11):2499-504. PubMed PMID:24048798
Birner P, Toumangelova-Uzeir K, Natchev S, Guentchev M. STAT3 tyrosine phosphorylation influences survival in glioblastoma. J Neurooncol. 2010 Dec;100(3):339-43.PubMed: 20455003
Guentchev M, McKay RD. Notch controls proliferation and differentiation of stem cells in a dose-dependent manner. Eur J Neurosci. 2006 May;23(9):2289-96. PubMed: 16706837
Kovacs GG, Gasque P, Ströbel T, Lindeck-Pozza E, Strohschneider M, Ironside JW, Budka H, Guentchev M. Complement activation in human prion disease. Neurobiol Dis. 2004 Feb;15(1):21-8. PubMed: 14751767
Guentchev M, Siedlak SL, Jarius C, Tagliavini F, Castellani RJ, Perry G, Smith MA, Budka H. Oxidative damage to nucleic acids in human prion disease. Neurobiol Dis. 2002 Apr;9(3):275-81. PubMed: 11950273
Wanschitz J, Klöppel S, Jarius C, Birner P, Flicker H, Hainfellner JA, Gambetti P, Guentchev M, Budka H. Alteration of the serotonergic nervous system in fatal familial insomnia. Ann Neurol. 2000 Nov;48(5):788-91. PubMed PMID:11079543
Guentchev M, Voigtländer T, Haberler C, Groschup MH, Budka H. Evidence for oxidative stress in experimental prion disease. Neurobiol Dis. 2000 Aug;7(4):270-3. PubMed: 10964599
Guentchev M, Wanschitz J, Voigtländer T, Flicker H, Budka H. Selective neuronal vulnerability in human prion diseases. Fatal familial insomnia differs from other types of prion diseases. Am J Pathol. 1999 Nov;155(5):1453-7. PubMed: 10550300
Guentchev M, Groschup MH, Kordek R, Liberski PP, Budka H. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies. Brain Pathol. 1998 Oct;8(4):615-23. PubMed: 9804371
Guentchev M, Hainfellner JA, Trabattoni GR, Budka H. Distribution of parvalbumin-immunoreactive neurons in brain correlates with hippocampal and temporal cortical pathology in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol. 1997 Oct;56(10):1119-24. PubMed: 9329455