Spine literature: Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.

Summary (English)

Educational summary of peer-reviewed work on spinal disorders (not medical advice).

Article: Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.

Authors (excerpt): Marie Plante, Janice S Kwon, Sarah Ferguson, Vanessa Samouëlian, Gwenael Ferron

Overview: BACKGROUND: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking. METHODS: We conducted a multicenter, randomized, noninferiority trial comparing radical hysterectomy with simple hysterectomy including lymph-node assessment in patients with low-risk cervical cancer (lesions of ≤2 cm with limited stromal invasion). The primary outcome was cancer recurrence in the pelvic area (pelvic recurrence) at 3 years. The prespecified noninferiority margin for the between-group difference in pelvic recurrence at 3 years was 4 percentage points. RESULTS: Among 700 patients who underwent randomization (350 in each group), the majority had tumors that were stage IB1…

Full citation: Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.. The New England journal of medicine. PubMed: PMID 38416430; DOI: 10.1056/NEJMoa2308900.

Consult the original paper for methods, statistics, and clinical applicability.

Summary (Bulgarian)

Това е обобщение за пациенти и специалисти, базирано на официалното резюме в PubMed. Публикацията е в списание The New England journal of medicine и засяга теми, свързани с гръбначния стълб (диагностика, лечение или епидемиология — според съдържанието на оригиналната статия). Не замества очен преглед при лекар и не представлява персонализиран медицински съвет.

Заглавие: Spine literature: Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.

Оригинално резюме (английски, съкратено): BACKGROUND: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking. METHODS: We conducted a multicenter, randomized, noninferiority trial comparing radical hysterectomy with simple hysterectomy including lymph-node assessment in patients with low-risk cervical cancer (lesions of ≤2 cm with limited stromal invasion). The primary outcome was cancer recurrence in the pelvic area (pelvic recurrence) at 3 years. The prespecified noninferiority margin for the between-group difference in pelvic…

Source: Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.. The New England journal of medicine. PubMed: PMID 38416430; DOI: 10.1056/NEJMoa2308900.