Spine literature: Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation.

Summary (English)

Educational summary of peer-reviewed work on spinal disorders (not medical advice).

Article: Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation.

Authors (excerpt): Rajesh K Kharbanda, James Kennedy, Zahra Jamal, Matthew Dodd, Richard Evans

Overview: BACKGROUND: Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence the incidence of stroke. METHODS: We conducted a randomized, controlled trial across 33 centers in the United Kingdom. We randomly assigned 7635 participants with aortic stenosis in a 1:1 ratio to undergo TAVI with a CEP device (CEP group) or TAVI without a CEP device (control group). The primary outcome was stroke within 72 hours after TAVI or before discharge from the hospital (if discharge occurred sooner). RESULTS: A total of 3815 participants were assigned to the CEP group and 3820 to the control group. A primary-outcome event occurred in 81 of 3795 participants (2.1%) in the CEP group and in 82 of 3799 participants (2.2%) in the control group (difference, -0.02 percentage points; 95% confidence interval, -0.68 to 0.63;…

Full citation: Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation.. The New England journal of medicine. PubMed: PMID 40162661; DOI: 10.1056/NEJMoa2415120.

Consult the original paper for methods, statistics, and clinical applicability.

Summary (Bulgarian)

Това е обобщение за пациенти и специалисти, базирано на официалното резюме в PubMed. Публикацията е в списание The New England journal of medicine и засяга теми, свързани с гръбначния стълб (диагностика, лечение или епидемиология — според съдържанието на оригиналната статия). Не замества очен преглед при лекар и не представлява персонализиран медицински съвет.

Заглавие: Spine literature: Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation.

Оригинално резюме (английски, съкратено): BACKGROUND: Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence the incidence of stroke. METHODS: We conducted a randomized, controlled trial across 33 centers in the United Kingdom. We randomly assigned 7635 participants with aortic stenosis in a 1:1 ratio to undergo TAVI with a CEP device (CEP group) or TAVI without a CEP device (control group). The primary outcome was stroke within 72 hours after TAVI or before discharge from the hospital (if discharge occurred sooner). RESULTS: A total of 3815 participants were assigned to the CEP group and 3820 to the control group. A primary-outcome event occurred in 81 of 3795…

Source: Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation.. The New England journal of medicine. PubMed: PMID 40162661; DOI: 10.1056/NEJMoa2415120.