Trinity Medical Center I Dr. Marin Guentchev, MD, PhD Myeloma/Plasmacytoma

Myeloma/Plasmacytoma

ANATOMY OF THE SPINE

The human spine is formed by individual vertebrae and connective tissue discs in between. The vertebrae form the spinal canal. There are seven cervical, twelve thoracic, and five lumbar vertebrae. The intervertebral discs are the link between the individual vertebral bodies.
Normal anatomy of the spine. Longitudinal section and cross sections through the cervical, thoracic and lumbar spine.
The little joints that link the vertebrae together are known as facet joints. They help to stabilize the spine and, together with the intervertebral discs, allow a certain degree of mobility of the spinal cord. The spinal canal should be wide enough to allow nerve roots to float freely in cerebrospinal fluid. The front border of the spinal canal is built by the vertebral bodies and intervertebral discs, the side by the intervertebral joints (facets) and back by the ligamentum flavum (yellow band) and vertebral arches. Discs consist of an outer fibrous ring (annulus fibrosus), which surrounds an inner gel-like center (nucleus pulposus). The spinal cord and nerve roots lie within the spinal canal. The spinal cord extends downwards approx. to the 1st lumbar vertebra. Below, only nerve roots are present in the spinal canal. At the level of the intervertebral disc the nerve roots pass through the neural root foramina to exit the spinal canal. The spinal cord and nerve roots conduct electric-like signals from the skin and joints to the brain, and process of movement is initiated from the brain to the muscles.

DESCRIPTION

Plasmacytoma is one of the most common malignant tumors of the spine. It occurs most often after the 5th decade. The tumor is due to an uncontrollable increase in the number of plasmocytes (immune cells precursors). The tumor causes degradation (osteolysis) and weakening of the affected bone. The increasing numbers of tumor cells replace normal blood cells, leading to anemia and susceptibility to infections. The most frequent localization of this tumor is in the spine, ribs, collarbone, skull, pelvis and femur. When only one tumor is present, it is called plasmacytoma, when multiple are present, it is called multiple Myeloma. Multiple Myeloma/Plasmacytoma usually is preceded by a benign condition called monoclonal gammopathy, a condition of undetermined significance.

CAUSE OF SYMPTOMS

Acute compression of the spinal cord and/or nerve roots
Vertebral fracture

SYMPTOMS AND SIGNS

Severe back pain
Pain, numbness and weakness in the limbs
Unsteady gait (especially in dark rooms) Stiffness, numbness and weakness of the hands and legs Retention, or unintended urinary incontinence Numbness of the genitals and loss of sexual function

THE DIAGNOSIS IS BASED ON

Medical history Clinical exam Computer tomography Magnetic resonance imaging (MRI) Radiographs

TREATMENT

Usually treatment is surgical
Non-surgical treatment may include
Radiation therapy Chemotherapy Opioids Nonsteroidal anti-inflammatory drugs Corticosteroids

WHEN SHOULD AN OPERATION BE PERFORMED?

WHAT IS THE GOAL OF SURGERY?

Complete tumor removal
Obtaining material for histological examination
To release the compressed nerve roots and/or spinal cord
To preserve the protective function of the spine

HOW IS SURGERY PERFORMED?

WHICH OTHER DISEASES SHOULD BE EXCLUDED (DIFFERENTIAL DIAGNOSIS)?

Another spine tumor Spondylodiscitis learn more ...
Adress
Trinity Medical Center 117 Zaichar St /Ground floor/ /Konstantin Velichkov Metro Station/ BG-1309 Sofia, Bulgaria
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